Notre Dame of Greater Manila is a member of the Philippine Accrediting Association of Schools, Colleges, and Universities since 1976, and was recently awarded a 5-year re-accreditational status by the said institution, the highest in CAMANAVA area and among the highest in the Philippines.

The school has also been a member of the Notre Dame Educational Association, a group of around 152 Notre Dame Schools in the Philippines, and the Oblates Educational Association, a group of academic institutions around the world owned and administered by the Oblates of Mary Immaculate. It is also a member of the Catholic Educational Association of the Philippines  and the Kalookan Diocesan Schools Association (KADSA), an umbrella organization of the Roman Catholic Diocese of Kalookan.

The school has been notable for being one among the members of the Philippine's largest Inter-school athletics organization's like the MILO BEST Pasarelle and SBP.